作者：徒建通伯 来源：原创 发布日期：08-23
一 | As speculation continues around who will take over the iconic role of James Bond after Daniel Craig’s exit, Shah Rukh Khan has finally reacted to the much-discussed question, could Bollywood’s biggest superstar ever slip into the 007 tuxedo? The actor, who is gearing up for his next film King, shared his thoughts during a conversation with BBC News India while in London for the unveiling of a bronze statue alongside his Dilwale Dulhania Le Jayenge co-star Kajol. View this post on Instagram A post shared by Shah Rukh Khan (@iamsrk) Craig’s retirement after No Time To Die has reignited global curiosity about the next face of the franchise. With names like Aaron Taylor-Johnson and Callum Turner leading the race for the role. So, when SRK was asked whether he would consider the role, his answer was equal parts humorous and humble. “No, I don't have the accent,” he laughed, adding, “I don't like shaken martini either.” Reflecting on his relatively late entry into action cinema, he joked that it was Kajol who unknowingly delayed his action phase. “I was always wanting to do an action film, but then Kajol was in my life, and you can't do action films when Kajol is acting opposite you. So I did all the romantic films!” Kajol playfully reminded him that he worked on many films without her, too, but SRK maintained that their iconic pairings defined a generation. View this post on Instagram A post shared by Shah Rukh Khan (@iamsrk) The actor was open about the notion of Bond, even if he acknowledged that he enjoyed his recent action parts. "I don't know about James Bond, but Sean Connery for sure, yeah!" he said, expressing his respect for the renowned original 007. Connery, Roger Moore, Pierce Brosnan, and Daniel Craig are among the actors who have starred in the James Bond series. The franchise is going through a change right now. The next instalment will be directed by Denis Villeneuve. Meanwhile, Shah Rukh Khan continues to dominate Bollywood. He is currently getting ready for King, which will be released in 2026 and co-star his daughter Suhana Khan, after winning a National Award for Jawan. Also Read: PHOTOS: Shah Rukh Khan and Kajol Inaugurate DDLJ-inspired Statue in Leicester。 我们对抗癌症--乃至所有疾病--的最大武器是我们的免疫系统，但即使它有时也需要一个帮手。免疫疗法提供了这种帮助，其中一种方法即所谓的免疫检查点抑制剂。这些药物能有效地解除免疫反应的自然刹车，从而使其能更长时间地跟癌症作斗争。尽管到目前为止这些药物看起来很有希望，但它们对一开始就没有什么免疫活动的“冷 ”肿瘤不起作用。因此，另一种类型的药物被称为STING激动剂，旨在将这些冷肿瘤激发为热肿瘤，从而使其更容易接受免疫疗法。但这些药物也有其缺点--即很难将它们瞄准癌细胞。
二 | 而这正是这项新研究的意义所在。来自耶鲁大学和URI的研究人员使用了一种叫做低pH插入肽(pHLIP)的分子来引导药物到它需要去的地方。pHLIP被吸引到酸性环境中，就像癌症在自身周围形成的那种环境一样，非常方便。该研究的论文共同作者Donald Engelman说道：“当pHLIP遇到具有中性pH值的细胞膜时，它将短暂地坐在表面，然后拉走。但如果它处于酸性环境中，那么该肽就会折叠成一个螺旋，穿过细胞膜并停留在那里。”该团队将pHLIP跟STING激动剂结合起来，从而使前者将后者带到癌细胞并帮助它们在内部开始工作。在小鼠身上的测试证明是有希望的--研究人员给20只患有小结肠肿瘤的小鼠注射了pHLIP-STING，发现在一次注射后，18只小鼠的肿瘤在几天内完全消失了。在另一组有较大肿瘤的小鼠中，10只小鼠中有7只看到它们的肿瘤完全消失。相比之下，另一组10只小鼠只接受了STING，它们没有pHLIP的指导。所有10只小鼠的肿瘤生长都略有减缓，但肿瘤仍然存在。这种治疗甚至似乎具有持久的效果。研究小组将新的癌细胞注射到已无肿瘤的小鼠体内，结果60天后没有新的肿瘤出现，这表明免疫记忆已经形成。虽然这项技术听起来很有希望，但通常的注意事项也是适用的--动物试验的结果并不总是能延续到人类身上。在任何基于pHLIP-STING的潜在治疗方法能够找到用途之前还需要做更多的工作。
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