一 | 在发表于《Oncotarget》杂志的一项研究中，约翰斯·霍普金斯大学医学院神经外科和肿瘤学教授Gregory Riggins博士和他的团队使用两种不同的小鼠模型来确定抗寄生虫药物甲苯达唑可以减缓或阻止早期和晚期胰腺癌的生长和扩散。
二 | SYDNEY, Australia -- Soccer officials in Australia and Indonesia have floated the idea of teaming up in a bid to rival Saudi Arabia for the hosting rights to the men’s World Cup in 2034.The Sydney Morning Herald reported comments Wednesday from Indonesia soccer federation president Erick Thohir about ongoing talks that could also include Malaysia and Singapore in a possible bid.Indonesia is being linked with a bid despite having the men’s Under-20 World Cup taken away by FIFA this year amid political turmoil because the Muslim-majority nation did not want to stage games involving Israel.Argentina ended up hosting the under-20 tournament at short notice.FIFA could have disciplined the Indonesian federation for breaching hosting duties but instead rewarded the country weeks later by naming it as host of the men’s Under-17 World Cup. Israel did not qualify for the under-17 edition, which starts next month.Thohir is an Indonesian government minister who has ties to FIFA president Gianni Infantino. Both are members of the International Olympic Committee and Thohir is a former president of Inter Milan, the Italian soccer club whose fans include Infantino.Any opponent to Saudi Arabia in the 2034 World Cup contest has to express official interest by Oct. 31. FIFA set a deadline of Nov. 30 to file a formal bidding agreement.Only members of the Asia and Oceania soccer bodies can apply to host the 2034 World Cup because the United States, Canada and Mexico will host the 2026 edition and six FIFA members from Europe, Africa and South America have joined for the 2030 tournament.Within hours of FIFA opening the 2034 contest a week ago, the Saudi Arabian soccer federation pledged to bid and Asian Football Confederation president Sheikh Salman bin Ebrahim Al Khalifa said there was united support for it. Four AFC members now appear to be in talks to contradict that statement.The Australian soccer federation, which successfully co-hosted the Women’s World Cup this year, said last week it is “exploring the possibility of bidding for the 2029 FIFA Club World Cup and/or the FIFA World Cup 2034.”The 32-team club event in 2029 is expected to be played in June-July, a time of year unsuited to the extreme summer heat in Saudi Arabia.FIFA has said it will decide which months to play the 2034 World Cup after its members confirm the host at a meeting likely to be held late next year.___AP soccer: https://apnews.com/hub/soccer。“我们认为甲苯咪唑可能在所有阶段都有作用，”Riggins说。“它对早期发现的胰腺癌特别有效。”Riggins和他的团队将甲苯咪唑注射到经过基因工程改造后患上胰腺癌的小鼠身上。该团队测量了炎症和组织的变化，以及每个肿瘤的阶段、分级和转移状态。甲苯咪唑最初是通过切断寄生虫的营养供应来对抗蛔虫、钩虫和其他寄生虫感染，它能抑制微管蛋白的形成。Riggins解释说，微管蛋白既是细胞内部的微观“骨架”，也是“运输的高速公路”。
三 | 该药物进入寄生虫的肠道并破坏微管蛋白，使寄生虫饿死。该研究表明，甲苯咪唑可能在胰腺癌中发挥类似的作用，通过塌陷癌细胞的结构，同时还有其他机制，如减少炎症。Riggins说，他希望通过人体临床试验继续他的团队的研究：“我们主张将甲苯咪唑作为一种疗法用于那些在转移前被诊断出来的人，看看我们是否可以减缓或预防胰腺癌，”Riggins说。“对于那些更晚期的癌症患者，它可能是某些手术的替代方案。甲苯咪唑作为初始治疗后的一种疗法可能有实用价值，以防止15%至20%接受手术的胰腺癌患者的肿瘤复发。它还可能增加其余80%至85%的晚期患者对标准化疗反应的持久性。
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